S. Venkataraman, A. Chadha
2015
Citations
0
Influential Citations
6
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Optically pure ( S )-ethyl 3-hydroxy 4,4,4-trifluorobutanoate was prepared using the biocatalyst Candida parapsilosis ATCC 7330 by deracemisation of the racemic alcohol ester in high optical purity (96%) and yield (65%) and by asymmetric reduction from its prochiral ketone (ee up to 84% and yield 60%) under different reaction conditions. This study highlights the possibility of using the same biocatalyst to produce ( S )-ethyl 3-hydroxy 4,4,4-trifluorobutanoate using different strategies.