D. Lanfranchi, N. Baldovini, Gilles Hanquet
Dec 1, 2008
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Influential Citations
3
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Journal
Synthesis
Abstract
: Wieland-Miescher diketone analogue 1 is a widely used precursor for asymmetric synthesis of natural sesquiterpenes and diterpenes. We describe here a large-scale preparation (>125 g batches) ofenantiomerically pure compound 1 starting from propionyl chloride and using very simple and cheap reagents. A new one-pot sequence to the intermediate 2-methylcyclohexane-l,3-dione is also described.