B. Drouillat, K. Wright, J. Marrot
May 15, 2012
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0
Influential Citations
20
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract A robust and practical synthesis of each enantiomer of 2-methyl-azetidine-2-carboxylic acid, based on the use of ( S )-phenylglycinol as resolving agent, is described. This synthesis affords practical quantities of this quaternary amino acid suitably N- and C-protected for use in further peptide coupling. Synthetic highlights include the formation of the azetidine ring by intramolecular alkylation and the facile separation of the diastereoisomeric amides derived from phenylglycinol.