D. Taber, Q. Jiang
Aug 11, 2000
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron
Abstract
Abstract The enantiomeric prostaglandins, exemplified by ent-PGE2, are apparently produced in vivo by the nonenzymatic oxidation of arachidonic acid. To assess the physiological activity of ent-PGE2, it was necessary to prepare it by total synthesis. The key transformation in this synthesis was the equilibration of the kinetically prepared ent-15-E2t-isoprostane to ent-PGE2.