Masakazu Kogami, N. Watanabe
Jun 1, 2011
Citations
0
Influential Citations
1
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
A safe and efficient process for the preparation of ethyl 2-methylthiophene-3-carboxylate (5) was devised. This process provides several advantages over the precedents, involving operational simplicity, avoidance of the use of strong bases such as n-butyllithium and application of noncryogenic conditions, and enabled to prepare 5 in 52% overall yield from commercially available 2-methylthiophene on a multikilogram scale.