Jiang Cheng-jun
2009
Citations
0
Influential Citations
1
Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate was synthesized from (S)-(-)-epichlorohydrin by ring-opening with sodium cyanide to form (S)-4-chloro-3-hydroxybutyronitrile,which was subjected to alcoholysis,protection of hydroxyl group with hexamethyl disilazane,cyanidation and then deprotection with hydrochloric acid. The total yield was 57%.