Du Yanrong
1999
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Chinese Journal of Nuclear Mdeicine
Abstract
Objective To prepare 111 Inpentetreotide for clinical applications Methods The pentetreotide was synthesized in our own laboratory An OctreoScanlike kit containing our synthetic pentetreotide and a set of other reagents were made for labeling with 111 In With the kit, 111 Inpentetreotide could be prepared on site Results The product showed high labeling yield (99%) and good stability in vitro (95% up to 8 h after reconstitution) Biological properties were evaluated by pharmacological experiments The rapid blood clearance (1%ID/g by 30 min) and high urine excretion (20%ID of renal up to 4 h post administration) were observed in biodistribution study of the normal mice Moreover, high T/B ratios (366 up to 8 h postinjection) and T/NT ratios (T/blood 409012, T/muscle 500021 by 4 h), as well as good quality images were demonstrated in a pancreas tumor bearing mouse model Conclusions The pentetreotide ligand, kit and its 111 In labeling product, prepared in our laboratory, have a good physicochemical and biological properties for the clinical application as an imaging agent of somatostatin receptor positive tumors