M. Shafiee, Batool Hojati Najafabadi, M. Ghashang
Oct 1, 2013
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0
Influential Citations
17
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Journal
Research on Chemical Intermediates
Abstract
A simple, highly versatile, and efficient synthesis of functionalized piperidines is achieved by four-component cyclo-condensation of aldehydes, aromatic amines, and acetoacetic esters using magnesium hydrogen sulfate [Mg(HSO4)2] as a catalyst in acetonitrile as the solvent at room temperature. The key advantages of this procedure are high yields, easy work-up, and purification of products by non-chromatographic methods.Graphical Abstract