M. Shamsipur, F. Jalali
May 1, 2000
Citations
0
Influential Citations
23
Citations
Journal
Analytical Sciences
Abstract
imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxyl]phenyl]piperazine (I), is a highly effective broad-spectrum antifungal agent which is used to treat a wide variety of superficial and systematic mycoses.1,2 It has an advantage over other imizazole derivatives of producing adequate sustained blood levels following oral administration.3 Meanwhile, ketoconazole may cause some changes in cytochrome P-450dependent monooxygenase activities4,5 as well as in epoxide hydrolase activity.6 Due to the vital importance of ketoconazole determination in biological fluids and in pharmaceutical preparations, several chromatographic3,7–11 and spectroscopic12–16 methods for its quantitative determination have been reported. However, some of these methods need expensive equipment and/or are time consuming.