D. Laurent, J. Romine
Mar 25, 2009
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0
Influential Citations
3
Citations
Journal
Synthesis
Abstract
Synthetic access to oxazolyl-substituted heterocycles including oxazolylimidazoles, -thiazoles, and -oxazoles is gained from a masked α-halo ketone attached to the 2-position of the ox-azole ring. 3-Bromo-2,2-diethoxy-N-(2-oxoalkyl)propionamides readily cyclize to generate the key 5-substituted 2-(2-bromo-1,1-di-ethoxyethyl)oxazole intermediate.