Tae-Kyung Lee, Jeong-Hyun Choi, Jang-Woong Byun
Sep 8, 2008
Citations
1
Influential Citations
5
Citations
Journal
Tetrahedron Letters
Abstract
MBHA (4-methylbenzhydrylamine) resin is widely used as a solid support for the synthesis of carboxamides or peptide C-terminal amides. Herein, we report a new method for synthesizing MBHA resin by benzotriazole-mediated amidoalkylation. MBHA resin was efficiently prepared with N-[(benzotriazol-1-yl)(p-tolyl)methyl]formamide or N-[formamido(p-tolyl)methyl]formamide, and it showed excellent properties as a solid support.