W. Min
2015
Citations
0
Influential Citations
0
Citations
Journal
Guangzhou Chemical Industry
Abstract
An organic experiment design for a drug intermediate,methyl 2-hydroxy-2,2-di( thiophen-2-yl)acetate,could be achieved from 2-bromothiophene as raw material through Grignard reagent treated with dimethyl oxalate with 55. 3% yield. This experiment could be carried out in an undergraduate course Organic Chemistry Experiments,and improved the interest of students to participate in the scientific research and experimental skills.