Wang Yong-mei
2007
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Journal
Chinese Journal of Pharmaceuticals
Abstract
N-2-(4-Methoxyphenyl)-1-methylethylbenzylamine,a key intermediate for antiasthmatic formoterol,was synthesized from 1-(4-methoxyphenyl)propan-2-one and N-benzylformamide in one pot via N-benzylation,Leuckart reaction and acidic hydrolysis with an overall yield of 46%.