B. Clark
Oct 1, 1976
Citations
0
Influential Citations
0
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Methyl nicotinate-5-2H was prepared in dry tetrahydrofuran by palladium-catalyzed deuterolysis of methyl 5-bromonicotinate. Acid hydrolysis of the crude reaction mixture resulted in a 92% yield of deuterium-labeled nicotinic acid of which 80 mole% was nicotinic-5-2H acid and 12 mole% was nicotinic-5-2H acid containing an additional deuterium atom elsewhere in the molecule. The structure assignment was based on the results of nuclear magnetic resonance spectroscopy, mass spectroscopy, ultraviolet spectroscopy, and elemental analysis.