M. El-Gaby, N. Taha, J. Micky
2002
Citations
0
Influential Citations
18
Citations
Quality indicators
Journal
Acta Chimica Slovenica
Abstract
Various sulfa drugs were coupled with active methylene compounds to give various hydrazones 2a-e. The reactivity of hydrazones 2a-e towards hydrazines was investigated. Thus, a novel series of 3, 5- diaminopyrazoles 3, 5, 6, 7a, and b and 9a, b were obtained by treatment of 2 with hydrazines. Pyrazolo[1,5-a][1,3,5] triazine derivatives 10, 11 and 12 were synthesized by interaction of aminopyra-zole 9a with triethyl orthoformate, acetic anhydride and benzoyl chloride, respectively. When aminopyrazole 6 and 8 were allowed to react with ketene dithioacetal 13, the novel pyrazolo[1,5-a] pyrimidine 15a,b were obtained. Structures of the new compounds were established by their elemental analysis and spectral data. Some of the synthesized compounds were tested in vitro for their antimicrobial activity.