Wu Zong-ka
2015
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Journal
Fine chemicals
Abstract
( Tetrahydrofuran-3-yl) methanol enantiomers were converted to two( tetrahydrofuran-3-yl)methyl-camphor sulfonate diastereomers with( D)-( +)-10-camphorsulfonic chloride,and the diastereomers were then separated by kinetic resolution to get( +)-( tetrahydrofuran-3-yl) methylcamphor sulfonate. The separated( +)-( tetrahydrofuran-3-yl) methyl-camphor sulfonate was dissociated from sodium hydride / benzyl alcohol to give( S)-( +)-( tetrahydrofuran-3-yl) methanol,The ee value is 99,and the yield is 85%. The intermediate further reacted with( 1,5-Dimethyl-[1,3,5]triazinan-2-nitro imino)-hydrazine to prepare( S)-( +)-dinotefuran.