A. E. Abdel Megied, O. Ali, T. Kofoed
Feb 26, 2001
Citations
0
Influential Citations
2
Citations
Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
Deprotected compounds 1 and 9 were allowed to react with 4,4′- dimethoxytrityl chloride in pyridine to give 5′-O-DMT nucleosides 2 and 10. The 3′-phosphoramidites 4 and 11 were incorporated into oligodeoxynucleosides (ODNs). The hybridization properties of the modified ODNs with their complementary DNA strands were studied. Interesting results were obtained when 11 was inserted as a bulged nucleoside into TWAs, duplexes, and triplexes.