J. Cabaj, Julie M. Lukesh, R. Pariza
Jan 5, 2009
Citations
0
Influential Citations
10
Citations
Journal
Organic Process Research & Development
Abstract
A manufacturing-scale process for the preparation of p-menth-2-ene-1,8-diol, a key intermediate for the preparation of Δ-9-tetrahydrocannabinol (Δ-9-THC), was developed. The process entails a large-scale olefin migration/epoxidation and hydrolytic epoxide opening in organic solvent. The water-soluble product is isolated without the need for exhaustive extraction.