M. Mahkam, N. Sharifi-Sanjani
2003
Citations
0
Influential Citations
36
Citations
Journal
Polymer Degradation and Stability
Abstract
Abstract Cubylamines and cubylmethylamines are of interest as antiviral agents. New biodegradable polyurethanes and polyetherurethanes having hydrolytically labile morphine groups as a therapeutic agent were prepared by reacting 1,4-diisocyanatocubane (DICC) with morphine. The polyetherurethanes containing morphine were prepared by reacting poly(ethylene glycol) with an excess of DICC to obtain a prepolymer which was reacted with morphine, which contains two hydroxyl groups. The structure of the polymers was confirmed by FTIR and 1 H NMR spectroscopy. The hydrolysis of drug-polymer conjugates was carried out in cellophane membrane dialysis bags containing aqueous buffer solution (pH 8) at 37 °C. UV spectroscopy was used to show that both 1,4-diaminocubane (DAC) and morphine were released by hydrolysis of the polyurethane segments. The polyurethane drug conjugates have longer duration of activity, due to slow release of DAC and morphine.