E. Ferrer, M. Wiersma, B. Kazimierczak
Sep 1, 1997
Citations
0
Influential Citations
18
Citations
Journal
Bioconjugate chemistry
Abstract
The behavior of oligonucleotides containing 5-iodouracil, 5-bromocytidine, and 5-iodocytidine in concentrated ammonia is described. 5-Aminouracil and 5-aminocytidine are obtained as side products when deprotection is performed at 60 degrees C. Small amounts, if any, of side products are obtained when ammonia deprotection is performed at room temperature. The base-pairing properties of these 5-halopyrimidines including triple helix are described.