Guo Jian-jun
2013
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Journal
Chinese journal of veterinary science
Abstract
The formulation of butenafine hydrochloride nanoemulsion was optimized by drafting the pseudoternary phase diagrams,its quality and safety were evaluated.The results showed that this oil-in-water nanoemulsion exhibited a spherical shape without adhesion or aggregation observed by TEM.The average diameter was 12.8 nm and the polydispersity index(PDI) was 0.137,with the zeta potential being(-10.3±0.1) mV.According to the established HPLC method,there was a good linear relationship within the range of 30-150 mg/L(r2=0.999 6),with the average recovery being(99.95±0.18)% and the relative standard deviation(RSD) being 0.18%.This preparation of butenafine hydrochloride nanoemulsion showed good stability for a long time,without toxicity or irritation.The nanoemulsion could be used as antifungal skin drug for potential clinical applications.