Chen Xue
2011
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Quality indicators
Journal
Progress in Modern Biomedicine
Abstract
Objective: To prepare nolatrexed dihydrochloride liposmes (NDL)and detect their correlative parameters. Methods: The nolatrexed dihydrochloride liposomes were prepared by film dispersion-extrusion combined with the ammonium sulphate gradients method. The UV detector with Sephadex G50 was utilized for the determination of the drug entrapping efficiency of liposomal nolatrexed dihydrochloride. The disposition of particle diameter was investigated by transmission electron microscope(TEM) and laser particle ana- lyzer And the entrapment efficiency and characteristic of drug release in vitro were detected by UV method. Results: The mean diameter of the nolatrexed dihydrochloride liposomes was 103.5±26 nm, with the entrapping efficiency of 83.6 %±2.37%. From the drug release experiment, about 66.5% nolatrexed dihydrochloride was released from the lipidosome after 24 hours. Conclusion: The new prepared li- posomes have good characteristics both in distribution and size, and it also can reach the purpose of slow-release effectiveness in-vitro, but the entrapping efficiency percentage still need to be further lifted.