Simin Fu, Gang Xu, Yongjun Chen
2012
Citations
0
Influential Citations
2
Citations
Journal
Chinese Journal of Organic Chemistry
Abstract
p > Abstract Enantiomerically pure ( R )-1-(2-naphthyl)ethylamine was firstly prepared by an efficient enzymatic kinetic resolution process. The effects of lipases, solvents, acyl donors, substrate concentration and temperature on the reaction were inves-tigated. It was found that as the acyl donor, 4-chlorophenyl valerate could effectively inhibit the non-selective amidation reaction. The optimal solvent, amine concentration and temperature were toluene, 300 mmol/L and 40 ℃ , respectively. Under the optimal conditions mentioned above, an excellent ee p value ( > 99%) at high conversion (50%) in 8 h could be achieved on the kinetic resolution reaction catalyzed by Novozym 435 with the new acyl donor.