Shiwen Xia, Hui Lin, Yongzheng Chen
Mar 1, 2012
Citations
1
Influential Citations
3
Citations
Journal
Chinese Chemical Letters
Abstract
(R)-2-Chloro-1-(m-chlorophenyl)ethanol, a precursor of (R)-3-chlorostyrene oxide which is the key chiral intermediate for the preparation of several beta 3-adrenergic receptor agonists was prepared in 40% yield and 99% ee by the Lipozyme TL IM-catalyzed second resolution of the corresponding racemate in the presence of vinyl acetate. (C) 2012 Shi Wen Xia. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.