S. Xie, X. J. Liu, Y. X. Zhang
Oct 1, 1992
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Influential Citations
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Journal
Journal of Macromolecular Science, Part A
Abstract
Abstract Rotundine, an analgesic drug, has been entrapped in a PIC polysaccharide granule. It was prepared in a two-step process, i.e., first granulation of a chitosan acetated solution containing Rotundine and then complexation of the polycationic component on the granular surface with a polyanionic solution of carboxymethyl glucomannan (CMGM). The granule has an average diameter of 1.38–1.53 mm and the drug content reaches 62.8%. The external release tests show that the T 50 is at 45 min and total release period is 4 h, while in an artificial intestinal fluid no more than 60% of the drug has been released within 4 h. Some factors affecting the external release were examined, which included the DS of CMGM and its aqueous concentration, preparation and after-treatment conditions, etc.