J. Jarý, V. Grossmann, S. Doležal
Aug 1, 1989
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Influential Citations
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Starting from [1-14C]ethanol 1,2-dibrom-[14C]-ethane was prepared by an usual method through [14C]-ethylene. Sodium sulfite was alkylated by 1,2-dibrom–[14C]ethane and the formed sodium 2-brom-[14C]ethane sulfonate was transferred without isolation to a labelled 2-[(aminoiminomethyl)thio]-[14C]ethanesulfonic acid. After purification by crystallization of the acid 2-mercapto-[14C]ethanesulfonic acid was prepared through guanidinium salt. After the neutralization of 2-mercapto-[14C]ethanesulfonic acid by sodium hydroxide the corresponding sodium salt with specific activity 0.083 μCi/mmol (0.31 MBq/mmol) was prepared.