H. Sakaguchi, H. Anzai, T. Fujita
Jul 25, 1977
Citations
0
Influential Citations
2
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
Copper (II), cobalt (II), nickel (II), and zinc (II) complexes of 2-hydrazino-4-hydroxy-6-methylpyrimidine were synthesized, and their infrared (IR) and nuclear magnetic resonance (NMR) spectra were examined. In the IR spectra of the complexes, the amide-I (carbonyl) bands were present and it was assumed that the ligand molecules were coordinated in the keto form of the isocytosine ring. The low frequency shift of the NH2 stretching bands by about 40-45 cm-1 on combining with Cu and Co indicated the formation of a metal-nitrogen bond. Preferential broadening of methine proton to methyl proton in the NMR spectra of the complexes of 2-hydrazino-4-hydroxy-6-methylpyrimidine can be explained by the binding of Co (II), Cu (II), and Ni (II) to N (3) site of the isocytosine ring. An ESR spectrum of the copper (II) complex would suggest the presence of copper (II) ion in a square-pyramidal conformation.