Lang Sun, Peng Liu, Jing Wang
Jul 31, 2017
Citations
0
Influential Citations
12
Citations
Journal
The Journal of organic chemistry
Abstract
The sulfuric acid-promoted cascade cyclization of 2-(3-hydroxyprop-1-ynyl)benzonitriles led to an efficient synthesis of spiro[indene-1,1'-isoindolin]-3'-ones. This class of spiro compounds could also be prepared by the sulfuric acid-catalyzed cyclization of 2-(phenylacryloyl)benzonitriles, which were readily derived from 2-(3-hydroxyprop-1-ynyl)benzamides using trifluoroacetic acid as a catalyst.