M. Mazza, F. Pavanetto, L. Montanari
Dec 1, 1980
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Journal
Il Farmaco; edizione scientifica
Abstract
A series of 1,3-benzodithiols substituted at position 2, obtained by condensation of benzene 1,2-dithiols with aldehydes and ketones, was studied for antifungal activity. The fungistatic activity of the compounds [Table I, II; (I leads to XXV)] was tested in vitro against the four strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results indicate at the 2-monosubstituted 1,3-benzodithiols are an interesting class of antifungal substances, the 2-phenyl substituted derivative (1) being of particular interest.