S. Tanabe, Y. Ogasawara, M. Nawata
Oct 25, 1989
Citations
0
Influential Citations
5
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
Sodium 3-mercaptopyruvate (3-MP), which is a sulfur donor substrate for sulfurtransferases, was synthesized directly from 3-bromopyruvic acid in anhydrous methanol at 4°C, by employing sodium hydrosulfide as a sulfhydryl compound instead of hydrogen sulfide gas. The purity of 3-MP was determined to be 97.9 and 98.6% by assay with N-ethylmaleimide and with reduced sodium adenine dinucleotide and lactate dehydrogenase, respectively.