J. Scott, Sarah E. Brewer, A. Davies
Jul 1, 2004
Citations
0
Influential Citations
5
Citations
Journal
Synlett
Abstract
The generation of 2,5-difluorophenyl lithium 2 by lithiation of 1,4-difluorobenzene with BuLi in THF, with and without amine additives, has been surveyed. Thermal stability data of the organolithium species 2 generated with and without TMEDA were determined and the synthetic utility of 2 in the addition to aldehyde and ketone electrophiles is described. Preparation and stability of the corresponding organomagnesium reagent 1, generated by bromine-magnesium exchange of 1-bromo-2,5-difluorobenzene with isopropylmagnesium chloride, was also examined.