Yang Jian-she
2007
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Journal
Fine Chemical Intermediates
Abstract
α-Chloropropionylglycine,a key intermediate of tiopronin was prepared by improved procedures including in the successive salting out and extraction. The whole sythesis processe of tiopronin were optimized. The total yield increased from 31.9% in literature reported to 55.9% on the basis of α-chloropropionyl chloride. The improved precess and procedure are more suitable for industrial production because of higher yield and lower cost.