Deng Yong
2001
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Journal
Chinese Journal of Pharmaceuticals
Abstract
A facile preparation of trans 1 isocyanato 4 methylcyclohexane(1) is described. Reduction of starting material p cresol with H 2/Raney Ni, oxidation with sodium hypochlorite solution mediated by TEMPO, oximation with NH 2OH·HCl, then reduction by Zn/CH 3COOH gave trans 4 methylcyclohexylamine(5). 1 was synthesized by reaction of 5 with triphosgene. The overall yield was 34.5%. This method has the advantages of mild reaction, low cost and less waste.