R. Duke, R. Allan, C. Drew
Jun 1, 1993
Citations
0
Influential Citations
11
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A synthesis of [3H]E- and [3H]Z-4-aminobut-2-enoic acids from methyl 4-N-phthalimidobut-2-ynoate by catalytic hydrogenation using tritium gas in the presence of a homogeneous catalyst, tris(triphenylphosphine)rhodium(I) chloride, is reported. HPLC separation of the E- and Z-isomers, and the saturated analogue, 4-aminobutanoic acid (GABA), is also described.