H. Sharma, S. Pradhan, Babita Sarangi
2010
Citations
1
Influential Citations
30
Citations
Quality indicators
Journal
International Journal of PharmTech Research
Abstract
Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic conditions, enteric delivery systems are required. The purpose of this study was to prepare Pantoprazole loaded microbeads by ionotropic gelation technique using sodium alginate and natural Mucoadhesive substance from the fruit of Dillenia indica followed by a coating with Eudragit L100-55. The microspheres have been characterized in terms of their morphology, particle size, encapsulation efficiency, swelling ratio, mucoadhesivity and ability of stabilizing Pantoprazole in acidic media. Different formulation variables like polymer-polymer ratio, drug-polymer ratio and coating concentration were considered. Almost spherical microbeads were obtained with sufficient swelling, Mucoadhesive property and acid resistance. Dissolution study was followed at phosphate buffer (pH 7.4) for 8 hr.