Theodore S. T. Wang, R. Fawwaz, R. V. Heertum
Nov 1, 1993
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
1,2-Dimethoxy-4-(bis-diethylaminoethyl-[14C]-amino)-5-bromobenzene (III) was synthesized for in vivo pharmacokinetic and pharmacodynamic evaluation. The synthesis of (III) was easily obtained by the direct alkylation of 1,2-dimethoxy-5-bromo-aniline with beta-diethylaminoethyl chloride-ethylene-[14C], using CH3MgCl as the proton abstractor. Compound III was obtained with a 22.3% yield. The specific activity was 2.2mCi/mmol, with a radiochemical purity of >99%.