M. Yamashita, Naohiro Taya, Mitsuyoshi Nishitani
Sep 15, 2015
Citations
1
Influential Citations
1
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract The novel triple reuptake inhibitor ( S )-4-(1-(3,4-dichlorophenyl)-2-methoxyethyl)piperidine monohydrochloride 1 possesses a unique 2-phenyl-2-(piperidin-4-yl)ethanol moiety with a stereogenic center at the benzyl position. To synthesize 1 as the ( S )-isomer, three possible routes were investigated; (1) the lipase-catalyzed kinetic resolution of tert -butyl 4-(1-(3,4-dichlorophenyl)-2-hydroxyethyl)piperidine-1-carboxylate 2 utilizing PS-IM from Pseudomonas sp. as the lipase; (2) the asymmetric hydrogenation of tert -butyl 4-(1-(3,4-dichlorophenyl)-2-oxoethyl)piperidine-1-carboxylate 5 utilizing dynamic kinetic resolution; and (3) the resolution of racemic [1-( tert -butoxycarbonyl)piperidin-4-yl](3,4-dichlorophenyl)acetic acid 8 with ( S )-phenylethylamine. The design of the asymmetric reaction using retrosynthesis, as well as the extensive exploration of enzymes, asymmetric hydrogenation catalysts, and resolving reagents, were all important to afford the optically active compound 1 in excellent yield.