Robert Du Ho Kim, Michele M. N. Wilson, J. Haseltine
Nov 1, 1994
Citations
0
Influential Citations
14
Citations
Journal
Synthetic Communications
Abstract
Abstract Hexahydropyrimidopyrimidine 3 is condensed with an alkyl ditosylate 4 at room temperature in DME or toluene. The resulting tricyclic salt is reduced with sodium borohydride to provide orthoamides 6a-c. Acidic hydrolysis of these orthoamides gives the corresponding macrocyclic triamines 8a-c in high yield.