S. Kagota, E. Chia, J. McGuire
Sep 1, 2011
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Journal
British Journal of Pharmacology
Abstract
In non‐obese diabetic animals, protease‐activated receptor‐2 (PAR2) agonists are more effective vasodilators, which is attributed to increased COX‐2 and endothelial NOS (eNOS) activities. Under conditions of diabetes and obesity, the effectiveness of PAR2 agonists is unknown. We compared the vasodilator responses of small calibre mesenteric arteries from obese diabetic B6.BKS(D)‐Leprdb/J (db/db) induced by PAR2‐activating agonists 2‐furoyl‐LIGRLO‐amide (2fly) and trypsin to those obtained in controls [C57BL/6J (C57)], and assessed the contributions of COX, NOS and calcium‐activated potassium channels (KCa) to these responses.