Scott C. Howard, J. Mccormick, C. Pui
Aug 5, 2016
Citations
37
Influential Citations
527
Citations
Quality indicators
Journal
The Oncologist
Abstract
High-dose methotrexate (HDMTX), defined as a dose higher than 500 mg/m2, is used to treat a range of adult and childhood cancers. Although HDMTX is safely administered to most patients, it can cause significant toxicity, including acute kidney injury. This article provides comprehensive recommendations for prevention of toxicity from HDMTX, along with detailed treatment guidance to mitigate acute kidney injury and subsequent toxicity.