H. Kanatani, H. Kohda, K. Yamasaki
Jun 1, 1985
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0
Influential Citations
45
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Journal
Journal of Pharmacy and Pharmacology
Abstract
Of the alkaloids obtained from Uncaria sinensis Oliv., geissoschizine methyl ether, corynantheine and dihydrocorynantheine decreased specific [3H]5‐HT binding to membrane preparations from rat brain and from in‐vitro experiments on guinea‐pig ileum, these alkaloids were found to be partial agonists for 5‐HT receptors. Therefore, they might be useful in the treatment of diseases resulting from disorders of 5‐HT metabolism.