Kapil S. Pandit, R. V. Kupwade, P. V. Chavan
Apr 28, 2016
Citations
0
Influential Citations
26
Citations
Journal
ACS Sustainable Chemistry & Engineering
Abstract
A problem solving, environmentally benign, and diversity oriented protocol has been described for multicomponent synthesis of medicinally privileged 2-amino-3-phenyl (or methyl) sulfonyl-4H-chromenes by one-pot, three component condensation among aldehydes, phenyl (or methyl) sulphonyl acetonitrile, and α-naphthol, 3-dimethylamino phenol, 4-hydroxy-N-methyl-quinoline-2-one as well as 4-hydroxycarbazole, using diethylamine as an efficient organo catalyst. The catalyst employed is commercially available, inexpensive, and nontoxic. Ambient reaction conditions, very high yields, wide scope, and avoidance of conventional isolation as well as chromatographic purification have improved the practical utility of this protocol manifold.