A. Chevalier, Abdelaaziz Ouahrouch, A. Arnaud
Apr 9, 2018
Citations
0
Influential Citations
11
Citations
Journal
RSC Advances
Abstract
Indazole derivatives are currently drawing more and more attention in medicinal chemistry as kinase inhibitors. 1H-indazole-3-carboxaldehydes are key intermediates to access to a variety of polyfunctionalized 3-substituted indazoles. We report here a general access to this motif, based on the nitrosation of indoles in a slightly acidic environment. These very mild conditions allow the conversion of both electron-rich and electron-deficient indoles into 1H-indazole-3-carboxaldehydes.