R. W. Keenan
Mar 1, 1987
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Homovanillic acid (4-hydroxy-3-methoxyphenylacetic acid) was labeled with tritium by exchange reaction in tritiated water catalyzed by sulfuric acid. The product was obtained in good yield and specific activities sufficient be utilized in metabolic experiments. Reactions carried out under identical conditions, but in the presence of deuterated water gave a product in which all the aromatic hydrogens and those α - to the carboxyl group were replaced with deuterium indicating that the tritium-labeled homovanillic acid was labeled in these positions.