M. Potrzebowski, N. Stolowich, A. Scott
Mar 1, 1990
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0
Influential Citations
6
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A convenient two-step chemical synthesis of DL-[2-13C]-glutamic acid from methyl acrylate and diethyl acetamidomalonate is described. Synthesis of the Michael adduct (III) was effected in quantitative yield by employing strong amino bases as catalysts. The reactivities of three such catalysts, tetramethyl guanidine (TMG), 1,8-diazobicyclo [5,4,0]-undec-7-ene (1,5-5) (DBU) and 1,5-diazobicyclo [4,3,0] non-5-ene (DBN) were compared by 13C NMR and all are shown to catalyse the reaction quantitatively, however at markedly different rates.