A. Hermetter, F. Paltauf
Feb 1, 1981
Citations
0
Influential Citations
49
Citations
Journal
Chemistry and Physics of Lipids
Abstract
Abstract 1,2-Dipalmitoyl-, 1,2-distearoyl- and mixed chain 1,2-diacyl- sn -glycero-3-phosphocholines were synthesized by a modification of the method of Warner and Benson [7]. Glycerophosphocholine (GPC) cadmium chloride complex was acylated with imidazolides of the corresponding fatty acids in dimethylsulfoxide-tetrahydrofurane (DMSO-THF) using the methylsulfinylmethide anion as a catalyst. The imidazolides were used for the acylation step without prior isolation and purification. Phosphatidylcholines were obtained in yields over 70%, they were free of sn -1- and sn -2-isomers.