Bjarne E Nielsen, Henrik Gotfredsen, B. Rasmussen
Aug 27, 2013
Citations
0
Influential Citations
3
Citations
Journal
Synlett
Abstract
We describe straightforward protocols for the preparation of a number of 1,3,5-substituted 2,4,6-trimethoxybenzenes. A two-step procedure for the preparation of a 1,3,5- tris -methylamino-2,4,6-trimethoxybenzene and further synthetic elaboration of this key substrate to yield a triamide, a tricarbamate and three different triureas is described. We also present a computational (DFT) study that investigates the different possible conformations of the overcrowded benzene substrate and a single-crystal X-ray structure of one of the key intermediates.