Zhang Zhi-rong
2011
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Yunnan Chemical Technology
Abstract
2,2-difluoro-1,3-benzodioxol-4-aldehyde was the key intermediate of fungicide fludioxonil.The synthetic process of 2,2-difluoro-1;3-benzodioxol-4-aldehyde was studied in order to improve the yield and the purity of the product.The title compound was prepared from o-cresol as the raw material via five steps including one pot synthesis of 3-methyl-1,2-benzene-diol,and then etherification,chlorination,fluorination,and hydrolysis.Under the optimal condition,the total yield was 33.2%,and the purity was 99.7%.The structure of the resulting product was confirmed by IR、1H NMR.