Lokesh Pawar, R. Jayaramaiah, B. Krishnan
Aug 9, 2019
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Influential Citations
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Journal
Tetrahedron
Abstract
Abstract The development of a phase-appropriate manufacturing-scale synthesis of potassium 2-fluoro-6-hydroxyphenyltrifluoroborate was achieved. Investigations into improving the yield and robustness indicated that pH of the reaction medium is a critical process parameter. Additional development resulted in replacing tartaric acid with citric acid, resulting in improved process robustness and enabling scale-up to >10 kg.