Pan Fu-you
2009
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0
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
5-Chloro-1-methyl-4-nitroimidazole in overall yield of 61.3% was synthesized from diethyl ethaneioate by a four-step reaction of amination,cyclization,salt formation,and nitration. The structure was characterized by NMR,IR and MS. Two improvements were that 30%~40% methylamine aqueous solution was substituted for methylamine gas in amination,and crystal of 5-chloro-1-methylimidazole nitrate was separated out by adding nitric acid into acetone solution of cyclization product in salt formation.